I know this is an old question, however, I had the same problem with a user control which had SnapsToDevicePixels="True" and UseLayoutRounding="True"
with the code below the first label showed a blurred box, while the non-transformed one showed the text perfectly. I tried flowing up the snaps and rounding properties up to the hierarchy and in the end, the only thing that fixed this behavior was to apply UseLayoutRounding=" True" to the window. Applying it to any other children panel or user-control did not fix it.
<UserControl x:Class="MyApp.Controls.Indications"
xmlns="http://schemas.microsoft.com/winfx/2006/xaml/presentation"
xmlns:x="http://schemas.microsoft.com/winfx/2006/xaml"
xmlns:mc="http://schemas.openxmlformats.org/markup-compatibility/2006"
xmlns:d="http://schemas.microsoft.com/expression/blend/2008"
mc:Ignorable="d"
d:DesignHeight="300" d:DesignWidth="300"
SnapsToDevicePixels="True"
UseLayoutRounding="True">
<Stackpanel>
<Label
BorderBrush="Black"
BorderThickness="1"
HorizontalAlignment="Center">
<TextBlock
Width="100"
TextAlignment="Center"
Text="Left Outboard Actuator"
TextWrapping="Wrap">
<TextBlock.LayoutTransform>
<RotateTransform
Angle="90"/>
</TextBlock.LayoutTransform>
</TextBlock>
</Label>
<Label
BorderBrush="Black"
BorderThickness="1"
HorizontalAlignment="Center">
<TextBlock
Width="100"
TextAlignment="Center"
Text="Left Outboard Actuator"
TextWrapping="Wrap">
</TextBlock>
</Label>
</Stackpanel>
</UserControl>