Late to the party but here's what I have found (while stumbling upon same problem) .
It seems that WPF Window
does require UnmanagedCode
permission.
Excerpt from Pro WPF 4.5 in C#: Windows Presentation Foundation in .NET 4.5 by Matthew MacDonald.

And, here's the stack trace of exception, when WPF application deployed via ClickOnce in Partial Trust is run. Notice the call to DemandUnmanagedCode
function of SecurityHelper
from the constructor of Window
:
InnerException: System.Security.SecurityException
Message=Request for the permission of type 'System.Security.Permissions.SecurityPermission, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089' failed.
Source=mscorlib
StackTrace:
at System.Security.CodeAccessSecurityEngine.Check(Object demand, StackCrawlMark& stackMark, Boolean isPermSet)
at System.Security.CodeAccessSecurityEngine.Check(CodeAccessPermission cap, StackCrawlMark& stackMark)
at System.Security.CodeAccessPermission.Demand()
at MS.Internal.SecurityHelper.DemandUnmanagedCode()
at System.Windows.Window..ctor()
at WPFClickOnceDeploySample.MainWindow..ctor()
And, here's the full StackTrace:
System.Reflection.TargetInvocationException was unhandled
Message=Exception has been thrown by the target of an invocation.
Source=mscorlib
StackTrace:
at System.RuntimeTypeHandle.CreateInstance(RuntimeType type, Boolean publicOnly, Boolean noCheck, Boolean& canBeCached, RuntimeMethodHandleInternal& ctor, Boolean& bNeedSecurityCheck)
at System.RuntimeType.CreateInstanceSlow(Boolean publicOnly, Boolean skipCheckThis, Boolean fillCache)
at System.RuntimeType.CreateInstanceDefaultCtor(Boolean publicOnly, Boolean skipVisibilityChecks, Boolean skipCheckThis, Boolean fillCache)
at System.Activator.CreateInstance(Type type, Boolean nonPublic)
at System.RuntimeType.CreateInstanceImpl(BindingFlags bindingAttr, Binder binder, Object[] args, CultureInfo culture, Object[] activationAttributes)
at System.Activator.CreateInstance(Type type, BindingFlags bindingAttr, Binder binder, Object[] args, CultureInfo culture, Object[] activationAttributes)
at System.Activator.CreateInstance(Type type, Object[] args)
at CreateInstance(Type type, Object[] arguments)
at System.Xaml.Schema.SafeReflectionInvoker.CreateInstance(Type type, Object[] arguments)
at System.Xaml.Schema.XamlTypeInvoker.CreateInstance(Object[] arguments)
at MS.Internal.Xaml.Runtime.ClrObjectRuntime.CreateInstanceWithCtor(XamlType xamlType, Object[] args)
at MS.Internal.Xaml.Runtime.ClrObjectRuntime.CreateInstance(XamlType xamlType, Object[] args)
at System.Xaml.XamlObjectWriter.Logic_CreateAndAssignToParentStart(ObjectWriterContext ctx)
at System.Xaml.XamlObjectWriter.WriteStartMember(XamlMember property)
at System.Xaml.XamlWriter.WriteNode(XamlReader reader)
at System.Windows.Markup.WpfXamlLoader.TransformNodes(XamlReader xamlReader, XamlObjectWriter xamlWriter, Boolean onlyLoadOneNode, Boolean skipJournaledProperties, Boolean shouldPassLineNumberInfo, IXamlLineInfo xamlLineInfo, IXamlLineInfoConsumer xamlLineInfoConsumer, XamlContextStack``1 stack, IStyleConnector styleConnector)
at System.Windows.Markup.WpfXamlLoader.Load(XamlReader xamlReader, IXamlObjectWriterFactory writerFactory, Boolean skipJournaledProperties, Object rootObject, XamlObjectWriterSettings settings, Uri baseUri)
at System.Windows.Markup.WpfXamlLoader.LoadBaml(XamlReader xamlReader, Boolean skipJournaledProperties, Object rootObject, XamlAccessLevel accessLevel, Uri baseUri)
at System.Windows.Markup.XamlReader.LoadBaml(Stream stream, ParserContext parserContext, Object parent, Boolean closeStream)
at System.Windows.Application.LoadBamlStreamWithSyncInfo(Stream stream, ParserContext pc)
at System.Windows.Application.LoadComponent(Uri resourceLocator, Boolean bSkipJournaledProperties)
at System.Windows.Application.DoStartup()
at System.Windows.Application.<.ctor>b__1(Object unused)
at System.Windows.Threading.ExceptionWrapper.InternalRealCall(Delegate callback, Object args, Int32 numArgs)
at MS.Internal.Threading.ExceptionFilterHelper.TryCatchWhen(Object source, Delegate method, Object args, Int32 numArgs, Delegate catchHandler)
at System.Windows.Threading.DispatcherOperation.InvokeImpl()
at System.Windows.Threading.DispatcherOperation.InvokeInSecurityContext(Object state)
at System.Threading.ExecutionContext.runTryCode(Object userData)
at System.Runtime.CompilerServices.RuntimeHelpers.ExecuteCodeWithGuaranteedCleanup(TryCode code, CleanupCode backoutCode, Object userData)
at System.Threading.ExecutionContext.RunInternal(ExecutionContext executionContext, ContextCallback callback, Object state)
at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean ignoreSyncCtx)
at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state)
at System.Windows.Threading.DispatcherOperation.Invoke()
at System.Windows.Threading.Dispatcher.ProcessQueue()
at System.Windows.Threading.Dispatcher.WndProcHook(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam, Boolean& handled)
at MS.Win32.HwndWrapper.WndProc(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam, Boolean& handled)
at MS.Win32.HwndSubclass.DispatcherCallbackOperation(Object o)
at System.Windows.Threading.ExceptionWrapper.InternalRealCall(Delegate callback, Object args, Int32 numArgs)
at MS.Internal.Threading.ExceptionFilterHelper.TryCatchWhen(Object source, Delegate method, Object args, Int32 numArgs, Delegate catchHandler)
at System.Windows.Threading.Dispatcher.InvokeImpl(DispatcherPriority priority, TimeSpan timeout, Delegate method, Object args, Int32 numArgs)
at MS.Win32.HwndSubclass.SubclassWndProc(IntPtr hwnd, Int32 msg, IntPtr wParam, IntPtr lParam)
at MS.Win32.UnsafeNativeMethods.DispatchMessage(MSG& msg)
at System.Windows.Threading.Dispatcher.PushFrameImpl(DispatcherFrame frame)
at System.Windows.Threading.Dispatcher.PushFrame(DispatcherFrame frame)
at System.Windows.Application.RunDispatcher(Object ignore)
at System.Windows.Application.RunInternal(Window window)
at System.Windows.Application.Run(Window window)
at System.Windows.Application.Run()
at WPFClickOnceDeploySample.App.Main()
at System.AppDomain._nExecuteAssembly(RuntimeAssembly assembly, String[] args)
at System.AppDomain.nExecuteAssembly(RuntimeAssembly assembly, String[] args)
at System.Runtime.Hosting.ManifestRunner.Run(Boolean checkAptModel)
at System.Runtime.Hosting.ManifestRunner.ExecuteAsAssembly()
at System.Runtime.Hosting.ApplicationActivator.CreateInstance(ActivationContext activationContext, String[] activationCustomData)
at System.Runtime.Hosting.ApplicationActivator.CreateInstance(ActivationContext activationContext)
at System.Activator.CreateInstance(ActivationContext activationContext)
at Microsoft.VisualStudio.HostingProcess.HostProc.RunUsersAssemblyDebugInZone()
at System.Threading.ThreadHelper.ThreadStart_Context(Object state)
at System.Threading.ExecutionContext.runTryCode(Object userData)
at System.Runtime.CompilerServices.RuntimeHelpers.ExecuteCodeWithGuaranteedCleanup(TryCode code, CleanupCode backoutCode, Object userData)
at System.Threading.ExecutionContext.RunInternal(ExecutionContext executionContext, ContextCallback callback, Object state)
at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state, Boolean ignoreSyncCtx)
at System.Threading.ExecutionContext.Run(ExecutionContext executionContext, ContextCallback callback, Object state)
at System.Threading.ThreadHelper.ThreadStart()
InnerException: System.Security.SecurityException
Message=Request for the permission of type 'System.Security.Permissions.SecurityPermission, mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089' failed.
Source=mscorlib
StackTrace:
at System.Security.CodeAccessSecurityEngine.Check(Object demand, StackCrawlMark& stackMark, Boolean isPermSet)
at System.Security.CodeAccessSecurityEngine.Check(CodeAccessPermission cap, StackCrawlMark& stackMark)
at System.Security.CodeAccessPermission.Demand()
at MS.Internal.SecurityHelper.DemandUnmanagedCode()
at System.Windows.Window..ctor()
at WPFClickOnceDeploySample.MainWindow..ctor()
InnerException: