Your question is not descriptive enough. But what I understand is you have a running EI server and you need to modify the axis2.xml using the Integration studio.
The simple answer is no you cant modify the axis2.xml of an EI server using the Integration studio. The Integration studio is used to develop artifacts and can also be used to test the artifacts. But it is not developed to manage deployment configurations.
Update
The latest version of the Integration studio contains a micro integrator. For the micro integrator, we have introduced a config file deployment.toml (available in the conf directory) to make the configuration changes. At the start of the server, it will check for any changes in the deployment.toml and if there are no changes it will revert all the configurations.
Therefore you need to add the configurations in the deployment.toml instead of the axis2.xml file.
Refer to the following sample configuration and refer to the documentation [1] for more information regarding the configurations of the deployment.toml
[[transport.rabbitmq.listener]]
name = "AMQPConnectionFactory"
parameter.hostname = "localhost"
parameter.port = 5672
parameter.username = "guest"
parameter.password = "guest"
[1]-https://ei.docs.wso2.com/en/7.2.0/micro-integrator/setup/brokers/configure-with-rabbitMQ/