You need to typecast the pointer to the proper function type, keeping in mind that methods have two implicit arguments, self and _cmd. From Apple's runtime docs:
void (*setter)(id, SEL, BOOL);
int i;
setter = (void (*)(id, SEL, BOOL))[target methodForSelector:@selector(setFilled:)];
for ( i = 0; i < 1000, i++ )
setter(targetList[i], @selector(setFilled:), YES);
(Edit)
Keep in mind that the Method type is a struct, and in the ObjC2 runtime, it's opaque, so you don't have direct access to its members - you'll need to use method_getImplementation(myMethod)
to get an IMP that you can typecast like above.