Looking at the new comments, this appears to be (as the OP notes) MemoryStream
capacity limited. A slight annoyance in the protobuf spec is that since sub-message lengths are variable and must prefix the sub-message, it is often necessary to buffer portions until the length is known. This is fine for most reasonable graphs, but if there is an exceptionally large graph (except for the "root object has millions of direct children" scenario, which doesn't suffer) it can end up doing quite a bit in-memory.
If you aren't tied to a particular layout (perhaps due to .proto interop with an existing client), then a simple fix is as follows: on child (sub-object) properties (including lists / arrays of sub-objects), tell it to use "group" serialization. This is not the default layout, but it says "instead of using a length-prefix, use a start/end pair of tokens". The downside of this is that if your deserialization code doesn't know about a particular object, it takes longer to skip the field, as it can't just say "seek forwards 231413 bytes" - it instead has to walk the tokens to know when the object is finished. In most cases this isn't an issue at all, since your deserialization code fully expects that data.
To do this:
[ProtoMember(1, DataFormat = DataFormat.Group)]
public SomeType SomeChild { get; set; }
....
[ProtoMember(4, DataFormat = DataFormat.Group)]
public List<SomeOtherType> SomeChildren { get { return someChildren; } }
The deserialization in protobuf-net is very forgiving (by default there is an optional strict mode), and it will happily deserialize groups in place of length-prefix, and length-prefix in place of groups (meaning: any data you have already stored somewhere should work fine).