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I spend a good half a day trying various things to solve the following problem when running samtools running on OSX Catalina: dyld: Library not loaded: @rpath/libcrypto.1.0.0.dylib Referenced from: /Users/brownbear/opt/anaconda3/bin/samtools Reason: image not found Abort trap: 6

I couldn't even ask command line to tell me which version it was (although I believe it was 1.9), it seems that something in the pair of updated conda and OSX something broke it. I tried everything out there and nothing worked. My last attempt was this and it worked...

was a combination of the following: https://www.biostars.org/p/173414/

https://github.com/bioconda/bioconda-recipes/issues/13488

in summary I first did 

which samtools

found the directory, and did 

rm samtools

then ran 

conda install -c bioconda samtools=1.9=h8ee4bcc_1

After this samtools worked, when checking version this is the result: 

#samtools 1.10
#Using htslib 1.10.2

Happy coding all!

AAA.BioInfo
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    Thanks for sharing the solution, but "conda install -c bioconda samtools=1.9=h8ee4bcc_1" installs the older build which is not compatible with new packages, Package libcxx conflicts for: python==3.6.12=h6c3b2c9_0_cpython -> libffi[version='>=3.3,<3.4.0a0'] -> libcxx[version='>=10.0.0|>=4.0.1|>=9.0.1'] python==3.6.12=h6c3b2c9_0_cpython -> libcxx[version='>=11.0.0'] samtools==1.9=h8ee4bcc_1 -> ncurses[version='>=6.1,<6.2.0a0'] -> libcxx[version='>=4.0.1'] Although, if you install it in a virtual environment is possible. – Shrm Mar 23 '21 at 17:48
  • Unfortunately, error dyld: Library not loaded: @rpath/libcrypto.1.0.0.dylib raise again. – Shrm Mar 23 '21 at 18:00

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