Not 100% sure what you're asking. If you just want an empty solution with some pre-created folders, which would be a file just named yourProject.sln, go to whatever primary language you have installed (C++ in my case), and make an empty project. This will give you an empty solution file, with just one folder, it would be named yourProject in my case above, and a few project files related to the language. If you want to add a new project to this solution, go to:
File->Add->New Project. Fill in the rest with whatever application type your project/program needs to be. This is how it's done in C++, I don't know how to do it in, say C#. However, you didn't specify a language... So I'm not sure where to go to help you, Visual Basic? C++?