Firstly, please go through the documentation here. It is explained in detail. In the beginning of page, there is definition of 'Default'. Please check that.
Now coming to your specific question
By default command.default.execution.timeout.enabled
value is set to true. As you can see in this section. So with code like this
command.default.execution.timeout.enabled: false
you are overriding it to be false. Which means none of the calls will be timed out by hystrix. But you can also see in that same section, we can enable or disable for a particular instance using commandkey.
The same thing applies to command.default.execution.isolation.thread.timeoutInMilliseconds
We have a default value and we can also change this value for a particular commandkey.
Lets assume currently you have this
hystrix:
command.default.execution.timeout.enabled: false
command.default.execution.isolation.thread.timeoutInMilliseconds: 60000
After a few days you can add something like
command.myinstancekey.execution.timeout.enabled: true
In this case timeout is enabled for only myinstancekey and it will timeout in 60000 because it takes the value from
command.default.execution.isolation.thread.timeoutInMillisecond
If you have something like
command.myinstancekey.execution.isolation.thread.timeoutInMillisecond: 30000
Then 30000 is taken as timeout value for mysinstancekey