Yes, it is possible to change parameters during the search. SCIP will, for example, act on a switch of node selector priority by reordering the open nodes queue according to the new node selector's sorting strategy.
Note that in general, SCIP like other solvers does not expect that parameters are modified during the search, and weird combinations may kill the solution process.
If a certain parameter is "safe" to change during the solution process depends a bit on the particular implementation of the parameter. It should always be safe to adjust, e.g., separating/maxrounds
or other core parameters independent of a particular plugin. However, individual plugins may or may not work properly if they are enabled dynamically during the search, because they miss an initialization step.
You can have a look at src/scip/event_solvingphases.c
, which adjusts a couple of parameters by changing emphasis settings. Those parameters are certainly safe to be adjusted during the search.