Is taskset for CPU affinity applicable when trying to use L2 cache efficiently on a multi core processor in a virtualised environment like Amazon EC2?
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No, especially towards the smaller instances, there's heavy CPU sharing, you're dependent on what the other instances are doing with the CPU.

Frodo Baggins
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1What about for large instances, especially cluster compute instances? – gazarsgo Sep 10 '13 at 02:03
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2Amazon implies that you can use CPU affinity for larger cluster instances here: http://aws.typepad.com/aws/2013/01/ec2-for-in-memory-computing-the-high-memory-cluster-eight-extra-large.html – Pinko Apr 24 '14 at 00:47