You won't ever keep hackers from hacking your games, even if it does indeed have a backing server. Just look at all the unofficial world of warcraft servers. You can keep things relatively safe if you have a server, you keep its source code secure, and your game is meaningless without its server (think Dota 2 with no multiplayer capabilities...). Even then, you can't actually validate the player's every move, unless it's a turn based game and you actually send every move the server to be processed (this works in Hearthstone, for example, but not in WoW, hence all the anti-cheating tools). EA couldn't do it, Rockstar couldn't do it, Activision couldn't do it, even the mighty Denuvo couldn't do it, you certainly can't do it.
However, you should stop and ask yourself why you want your game to be that secure. Out of every 1000 cheaters you stop, maybe one or two would actually pay. You should put in a moderate amount of effort on security (take KYL3R's advice), simply to keep honest people honest. Dishonest people will always find a way, so don't worry about them so much that you end up wasting time on (useless) security; time you could spend on making your game better.
Oh and by the way, that's also one way to keep hackers out: frequent updates to the game. They have no life, but they don't have enough time to keep making a hacked version of every game on the market every week.