As Owen said in comments, your question is probably too broad and cannot receive acceptable answer. We can just provide you with a general procedure to follow.
In Open Refine, you'll need to create a column based on the messy column and apply transformations to delete unwanted characters. You'll have to use regular expressions. But for that, it's necessary to be able to identify patterns. It's not clear to me why the "ST" of "Nat.secu ST." is important, but not the "US" in "Massy Intertech US". Not even the "36" in "Plowk 36" (Google doesn't know this word, so I'm not sure is an organisation name).
On the basis of your fifteen lines, however, we seem to distinguish some clear patterns. For example, it looks like you'll have to remove the tokens (character suites without spaces) at the end of the string that contain a #. For that, the GREL formula in Open Refine could look like this:
value.trim().replace(/\b\w+#\w+\b$/,'')
Here is a screencast if it's not clear to you.

But sometimes a company name may contain a #, in which case you will need to create more complex rules. For example, remove the token only if the string contains more than two words.
if(value.split(' ').length() > 2, value.replace(/\b\w+#\w+\b$/, ''), value)
And so on for the other patterns that you'll find (for example, any number sequence at the end that contains more than 4 numbers and one - between them)
Feel free to check out the Open Refine documentation in case of doubt.