Which is better?
REST doesn't care; from the perspective of the client, the URI is opaque. The clients concerns are following links/submitting forms/completing templates.
Information encoded into the URI is done at the server's discretion and for its own exclusive use.
So you can use any spelling you like. As a rule, it's a good idea to conform to local spelling conventions (in much the same way that your variable names in code should conform to your coding conventions). But your clients shouldn't need to know the details of those conventions.
/users/{input}
...
if(isEmail(input)) queryByEmail(input);
else queryById(input);
Note that you aren't necessarily deeply committed to one approach; that's part of the point of decoupling the identifiers from the representations. For instance, your implementation could just as easily look like
/users/{input}
...
if(isEmail(input)) redirectTo(/users/email/{input});
else redirectTo(/users/id/{input});
which allows clients that have bookmarked the original URI to arrive at the correct resource.