If it's JavaScript doing the regex masking, you've already failed because JS should never need to know the original card number, except when you've just received it from the user and are sending it to the server for the first time, in which case you shouldn't be masking it anyway so the user can check for typos.
I can't really help you there, you've already failed in the worst way.
Server-side, if the number is already broken into spaces*, then one option is: (in PHP but the same idea applies to all)
$parts = explode(" ",$fullnumber);
$first = array_shift($parts);
$last = array_pop($parts);
$middle = implode(" ",$parts);
$mask = preg_replace("/\d/","*",$middle);
$result = "$first $mask $last";
* it shouldn't be