you can write your own custom validator.
something like
selfInspecting(validator: {val, obj -> /*test selfInspecting here*/})
EDIT -- in response to the other answer -- you can handle this on the form, but you should also handle it on the server.
ANOTHER EDIT -- It was suggested in a comment that you might want to validate one of two fields on your Domain class. This is also easily accomplished with a custom validator. With the signature above for the custom validator closure, the val is the value selfInspecting, and obj is the domain object instance. So you could have
{ val, obj ->
if (val == null) return false // if you want to ensure selfInspecting is not null
else return true
... or ...
// if you want to check that at least 1 of two fields is not null
def oneOrTheOther = false
if (obj.field1 != null || obj.field2 != null)
oneOrTheOther = true
return oneOrTheOther
}