Even if your objects only get initialized at request level, it seems like it should be less of a pain to work with in this fashion.
<cfscript>
request.DB.Datasource = "DatasourceName";
request.DB.Username = "DatasourceUsername";
request.DB.Password = "DatasourcePassword";
request.randomDAO = createObject('component','DAOStuff.randomDAO');
request.randomDAO.init(DBObject = request.DB);
request.someQuery = request.randomDAO.someGetter();
request.someOtherQuery = request.randomDAO.someOtherGetter();
request.aThirdQuery = request.randomDAO.aThirdGetter();
</cfscript>
As opposed to:
<cfscript>
request.DB.Datasource = "DatasourceName";
request.DB.Username = "DatasourceUsername";
request.DB.Password = "DatasourcePassword";
</cfscript>
<cfquery name="request.someQuery"
datasource=request.DB.Datasource
username=request.DB.Username
password=request.DB.Password>
--SOME SQL HERE
</cfquery>
<cfquery name="request.someOtherQuery"
datasource=request.DB.Datasource
username=request.DB.Username
password=request.DB.Password>
--SOME SQL HERE
</cfquery>
<cfquery name="request.aThirdQuery"
datasource=request.DB.Datasource
username=request.DB.Username
password=request.DB.Password>
--SOME SQL HERE
</cfquery>
If it is safe for your data objects to exist at an application level (assuming here that the data source for the object will not change at run-time and that you have written thread-safe CFCs) You can store and initialize DAOs at application level and then each request has wonderfully simple code like:
<cfscript>
request.someQuery = application.randomDAO.someGetter();
request.someOtherQuery = application.randomDAO.someOtherGetter();
request.aThirdQuery = application.randomDAO.aThirdGetter();
</cfscript>