Mine is not really a question, it's more of a call for opinions - and perhaps this isn't even the right place to post it. Nevertheless, the community here is very informed, and there's no harm in trying...
I was thinking about ways to create a highly scalable and, above all, highly modular back-end architecture. For example, an entire back-end ecosystem for a large site that had the potential for future-proof evolution into a massive site.
This would entail a very high degree of separation of concerns, to the extent that not only could (say) the underling DB be replaced (ie from Oracle to MySQL) but the actual type of database could be replaced (ed SQL to KV, or vice versa).
I envision a situation where each sub-system exposes its own API within the back-end ecosystem. In this way, the API could remain constant, whilst the implementation could change (even radically) over time.
The system must be heterogeneous in that it's not tied to a specific language. It must be able to accommodate modules or entire sub-systems using different languages.
It then occurred to me that what I was imagining was simply the architecture of the web itself.
So here is my discussion point: apart from the overhead of using (mainly) text-based protocols is there any overriding reason why a complex back-end architecture should not be implemented in the manner I describe, or is there some strong rationale I'm missing for using communication protocols such as Twisted, AMQP, Thrift, etc?
UPDATE: Following a comment from @meagar, I should perhaps reformulate the question: are the clear advantages of using a very simple, flexible and well-understood architecture (ie all functionality exposed as a series RESTful APIs) enough to compensate the obvious performance hit incurred when using this architecture in a back-end context?