The short answer is yes, you can. However, the W3C spec forbids it while the WHATWG spec allows it. As the author of the main
element wrote the W3C version and is at odds with WHATWG's interpretation, I would defer there. There is also an open bug to have the WHATWG spec align with the W3C spec.
However, you SHOULD NOT as the best use of main
involves supporting assistive technology (AT) (screen readers, for example). It also maps to the ARIA role of main, so it has a direct mapping expectation.
AT users have a quick way to navigate to the main
element, which represents the main content of the page. If you use more than one, then those users may never see it as they do not expect there to be more than one block of main content (the WHATWG bug report bears this out as stated by AT users).
Also the HTML validator will throw an error, which may or may not be a concern.
In most cases, multiple article
elements can be nested within a main
to achieve the desired effect for styling hooks.
I don't have enough rep points to post more than 2 links, else I'd offer some more material.