I'm running Visual Studio 2010 Premium on a Vista 32-bit machine and I've noticed that sometimes when I'm debugging a website project I can't edit an aspx file. If I close the file and open it again then I can edit it. Has anyone else encountered this problem? The only extensions I have installed are the VS Productivity Power Tools and Power Commands.
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What source control are you using? Do you have Visual Source Safe, Team Foundation Server, Visual SVN, etc? – hyprsleepy Sep 29 '10 at 19:01
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Sorry for the late reply. We're using TFS. I haven't noticed this problem in recent weeks and in that time there were a few update for the Power Tools add-on, so I suspect that the problem may have been there. – scumdogg Oct 18 '10 at 13:12
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Check: http://stackoverflow.com/questions/3450617/editing-aspx-ascx-files-randomly-disabled-in-visual-studio-2010 – David Feb 18 '13 at 06:28
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I also experience this problem (using Windows 7 or XP). This happens when:
- I don't already have the .aspx file open in Visual Studio 2010
- I am running the web app in debug mode
The file lock happens when I open and then try to edit an .aspx page (e.g. to tweak a bit of HTML) that I am currently viewing via a web browser when running the app in debug mode.
I've yet to find a solution for this problem however as a workaround I use "Browse With..." (Right click in Solution Explorer) to load and view the page(s) when I'm making HTML refinements. You can't debug code but it doesn't lock the files.

BradB
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