I have become a fan of what @SplungeBob showed me a long time ago. The code snippet below gives you an idea of what it takes to accomplish the GUI shown below it.
frame.add(menu, new GBConstraints( 0, 0).spanX(32).fill(HORIZONTAL));
frame.add(new JLabel("Available letters"),
new GBConstraints( 0, 1).insets( 2, 2, 0, 2));
frame.add(new JLabel("Play by play..."),
new GBConstraints( 2, 1).insets( 0, 5, 0, 0));
frame.add(pnlPlays, new GBConstraints( 2, 1).insets(10, 0, 0, 0).spanY(14).anchor(WEST).fill(BOTH));//.ipad(0,0));
frame.add(pnlAvail, new GBConstraints( 0, 2).insets(0, 5, 5, 5));
frame.add(pnlLegend, new GBConstraints( 1, 2) .spanY(14) .fill(BOTH));
frame.add(pnlBonuses, new GBConstraints( 0, 3).insets(0, 100, 0, 0));
frame.add(pnlSBBonuses, new GBConstraints( 0, 3).insets(0, 125, 0, 0));
frame.add(gamePanel, new GBConstraints( 0, 5).insets(0, 50, 0, 0));
frame.add(pnlTheScore, new GBConstraints( 0, 5) .anchor(EAST));
btnDebug.setPreferredSize(new Dimension(1, 1));
frame.add(btnDebug, new GBConstraints( 0, 0) .anchor(WEST));
frame.add(btnNextReplayStep,new GBConstraints( 0, 6).insets(0,310, 0, 0) .anchor(CENTER));
btnNextReplayStep.setVisible(false);
frame.add(new JLabel("User letters"),
new GBConstraints( 0, 6).insets(0,240, 30, 0));
frame.add(btnCopyUser, new GBConstraints( 0, 6).insets(0,310,0,0) .anchor(CENTER));
frame.add(btnCopyAllLetters,new GBConstraints( 0, 6) .anchor(EAST));
frame.add(pnlNotes, new GBConstraints( 0, 6).insets(25,10,10, 10).spanY( 2).anchor(WEST));
frame.add(btnClearMnemHi, new GBConstraints( 0, 7).insets(0,430, 0, 0));
frame.add(btnClearBorders, new GBConstraints( 0, 7).insets(0,530, 0, 0));

I won't lie; it can still be a major task, but with careful planning with an actual grid marked off in vertical and horizontal lines to show, e.g., how many columns a field must span
, it's worth a try. And chances are excellent that what @Hovercraft suggests is even better.
(I haven't mastered it, it seems as the weird insets
values seem to indicate. But it's a nice-looking reliable GUI.)
EDIT
Here's code for how two of the JPanel
objects were created prior to executing the code above. One also uses GridBagLayout
; other doesn't. Just whatever works easiest and best.
private void makePlays(){
pnlPlays = new JPanel(new GridBagLayout());
pnlPlays.setSize(500,300);
pnlPlays.add(scrPlays, new GBConstraints(0,1).span(40, 62)
.fill(BOTH).ipad(100, 50));
scrPlays.setEnabled(false);
}
private void makeScoremasterBonuses(){
BonusBackgroundColors c;
BonusBackgroundColors all [] = BonusBackgroundColors.values();
String labels[] = new String[all.length];
String abbrs [] = new String[all.length];
JButton but;
pnlBonuses = new JPanel();
pnlBonuses.add(new JLabel("Legend:"));
for (int i = 0; i < all.length; i++) {
labels[i] = all[i].name().replace("_", " ").toLowerCase();
abbrs [i] = Utilities.abbreviate(all[i].name());
c = BonusBackgroundColors.values()[i];
but = new JButton(abbrs[i]);
but.setToolTipText(labels[i]);
but.setBackground(c.background(c));
but.setHorizontalAlignment(javax.swing.SwingConstants.CENTER);
but.setActionCommand("" + i);
but.addActionListener(this);
pnlBonuses.add(but);
}
}