You can use if within your update clause:
update test_update set A=if(A is null, null, 'A2'), B=if(B is null, null, 'B2'), C=if(C is null, null, 'C2');
Example run:
MariaDB [test]> select * from test_update;
+------+------+------+
| A | B | C |
+------+------+------+
| A1 | NULL | NULL |
| NULL | B1 | NULL |
| NULL | NULL | C1 |
| A1 | B1 | NULL |
| A1 | NULL | C1 |
| NULL | B1 | C1 |
| A1 | B1 | C1 |
+------+------+------+
7 rows in set (0.00 sec)
MariaDB [test]> update test_update set A=if(A is null, null, 'A2'), B=if(B is null, null, 'B2'), C=if(C is null, null, 'C2');
Query OK, 7 rows affected (0.00 sec)
Rows matched: 7 Changed: 7 Warnings: 0
MariaDB [test]> select * from test_update;
+------+------+------+
| A | B | C |
+------+------+------+
| A2 | NULL | NULL |
| NULL | B2 | NULL |
| NULL | NULL | C2 |
| A2 | B2 | NULL |
| A2 | NULL | C2 |
| NULL | B2 | C2 |
| A2 | B2 | C2 |
+------+------+------+
7 rows in set (0.00 sec)