It is really difficult to give you an exact answer because you did not specifiy the architecture.
From my experience I can tell you that acces to the database und javascript in combination are fast enough to build a videomanager. You should consinder a smart concept behind the actual ressources. I would not load any content into a db as a blob or so. Your should only save the relative links to files in a directory.
You have multiple example of nwjs apps that are doing something similar. For example Atraci or Powder Player
You should try a building a simple App where you load a video and an mp3 from a file. If it is fast enough for you, than you can expect that I will not be problem building some javascript and db accesses arround it. It would say it is totally possible.
Download node-webkit. Install node-sqlite3 and try to move a file to a folder and save the link. Call the link on the next page and you will see.