I started to implement the solution by @EverettEvola but also where the validation logic was being called multiple times and displaying multiple ValidationSummary popups. My solution was as follows:
On the button (in my case the button was a submit button)
OnClientClick="return CustomValidationOnClick()"
And the CustomValidationOnClick()
function CustomValidationOnClick(source, args) {
//Manually kickoff page validation
//This call will display the Validation summary popup if page is invalid
Page_ClientValidate();
//Page_IsValid set by the result of the Page_ClientValidate() call
if (Page_IsValid == true) {
this.disabled=true;
return true; //if Submit button return true to continue form submit
}
else {
//do whatever here
return false; //if Submit button return false to cancel form submit
}
}