To send a message through TLS/SSL, you need to set Ssl of the SmtpClient class to true.
string to = "jane@contoso.com";
string from = "ben@contoso.com";
MailMessage message = new MailMessage(from, to);
message.Subject = "Using the new SMTP client.";
message.Body = @"Using this new feature, you can send an e-mail message from an application very easily.";
SmtpClient client = new SmtpClient(server);
// Credentials are necessary if the server requires the client
// to authenticate before it will send e-mail on the client's behalf.
client.UseDefaultCredentials = true;
client.EnableSsl = true;
client.Send(message);