I have done this a million times, i.e open the javascript file in the "Sources" tab, edit and hit CTRL+S to save it, upon which Chrome would confirm the same with a "Recompilation and Update Succeeded".
But I can no longer do this! There is no confirmation message in the console.
Also, the source window turns reddish indicating failure to do so.
The same script is getting edited from a different system.
I am on Chrome 41.0.2272.101m / WIN8.
The script is not "prettified", just to rule that answer out.!