In Famo.us prior to Mixed mode this has been an issue.
The new version will be addressing this issue and others that affect performance. There will be a full rewrite of the Engine in this new version.
Note: As of the date of this question, mixed mode has not been released to the public. Mixed mode will be allow rendering to WebGL and DOM. The current version is DOM only.
We are working on this in mixed mode. This is essentially gutting our
entire core composition & layout layers.
Things that get killed:
Entity Spec Parser
Things that will either change a lot or have its functionality and
purpose moved to other modules:
Context RenderNode Surface render/commit & more
Because this is such a huge overhaul, we need to take the time to
investigate how we can use our changes to improve the API. We are
really trying to codify our patterns and remove the bad habits we
started of subclassing our base classes, overuse of eventing, and
solving every problem through extra state.