The documentation for SPDY says it is not compatible with mod_php as its not thread safe:
https://developers.google.com/speed/spdy/mod_spdy/php
Much like the Apache Worker MPM, mod_spdy is a multithreaded module, and processes multiple SPDY requests from the same connection simultaneously. This poses a problem for other Apache modules that may not be thread-safe, such as mod_php. Fortunately, it is fairly easy to adjust your Apache configuration to make your existing PHP code safe to use with mod_spdy (and with the Worker MPM as well).
I have tried using SPDY with mod_php and I haven't had any issues. What is the danger of doing this?