Since this is a beta-1 release, Is there anything which I should especially be worried about?
3 Answers
I've used it for a long time and know several others that have done so without any problems. So I wouldn't be worried if I were you. But I haven't tested all the stuff like SQL queries and other db stuff you can do with drush. But it's really good for downloading modules, disabling/enabling modules, clearing cache and other stuff like that, that you tend to do a lot when developing.

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Drush is awesome. It does it's job well. The only thing to be wary of are things like:
- Have you modified any contrib modules yourself?
- "Stable" new releases may contain
bug(s) the maintainer did not
catch.
But Drush does provide a backup of contrib modules to /backups.

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Drush is pretty safe when it comes to install/uninstall modules or themes (usually it also makes back-ups) but KEEP in mind when you update the core to back-up your entire web site. I have some web sites that I do maintenance and are not build by me that if I run:
drush up
I get weird behavior like: a theme gets deleted (that was the way it was built, I found out that moving the theme from root/themes/themename to root/sites/all/themes/custom/themename fix the problem), or the whole website just stops working (the build contains double code modules folder like: root/modules and root/modules/modules). So in general if your web site is build with best practices, drush is awesome, if not you might run into trouble.

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