I've download latest ActivePerl and configured Web Site Extensions along with script mappings with .pl extension for target site in IIS 6.
Also did the exact same in IIS 7.5 and it worked.
The script I'm trying to execute is very simple "Hello World" first and then configure AWStats, which I'm also able to do in IIS 7.5 with no issues..
I'm hoping someone can point me in the right direction..
Thanks D