It looks like developing GUI applications in HTML+JS with python in the background would be really nice. I see node-webkit. I also see that there are python bindings for webkit. It just seems like it's an order of magnitude more difficult to set up than python/tkinter - and I couldn't find win7 support.
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Maybe what you are looking for is Pyjs, is not entirely build to do that, but that's the nearest thing to it I have found.

Leonardo
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