I'm playing around with the travelling salesman example provided with GLPK, and trying to get a feel for what problem size I can reasonably expect to solve. I've managed to solve a 50 node graph, but 100 nodes doesn't seem to be converging in a reasonable timescale (30 minutes or so on modern hardware).
GLPK has lots of options for the MIP solver. I've tried various combinations but I'm not at all clear what options might help. This page has some discussion but is somewhat out of date and the advice is rather general.
Is it reasonable to expect GLPK to solve a 100 node tour or greater in a practical time frame (say, less than 4 hours)? When does the problem size become intractable? Are any of the many command-line options likely to help?