Yes, you can add text effects for any range of characters that you want. Here is a code snippet in VB.net - sorry I don't do c#.
One way is to change the current font before you append new text:
rtbEmail.SelectionFont = New Font(rtbEmail.Font.Name, CSng(rtbEmail.Font.Size * 1.25))
rtbEmail.AppendText("To: " & emailparts.ToData & vbCrLf & "From: " & emailparts.FromData & vbCrLf & "Subject: " & emailparts.SubjectData & vbCrLf)
Another way is to define a beginning and end of a range of text:
highlightstart = rtbEmail.TextLength
rtbEmail.AppendText(msg.Message)
rtbEmail.SelectionStart = highlightstart
rtbEmail.SelectionLength = rtbEmail.TextLength - highlightstart
rtbEmail.SelectionFont = New Font("Courier New", rtbEmail.Font.Size, FontStyle.Regular)
HTH - Ken