I can think of a way to do this with CSS, but I rather jsut do it in a much cleaner way and just not have the code appear at all if nothing is entered into the Custom Field on the backend. Heres the code:
<li class="price">
<?php echo get_post_meta($post->ID, 'Price', true); ?>
</li>
And I tried this:
<?php if get_post_meta($post->ID, 'Price', true); { ?>
<li class="price">
<?php echo get_post_meta($post->ID, 'Price', true); ?>
</li>
<?php } ?>