I can not even find one Peer-Reviewed Double Blind Study of any vaccine.
Can you point out some studies for me, if they are available?
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4Search on Google for Polio. EVERY vaccine has peer-reviewed studies done before it is approved, then more come after. Vote to close (subjective and argumentative). – Ustice Mar 24 '11 at 18:22
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1@Daniel I suggest you run a quick [search on PubMed](http://www.ncbi.nlm.nih.gov/pubmed?term=vaccine%20efficacy) before you make such a bold statement. – Richard Stelling Mar 24 '11 at 18:24
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Please formulate this as a question, not as a statement. In this form the question is likely to be closed. You're just stating your conclusion (that vaccines don't work) already in your question, this is not a forum, you're supposed to ask questions, not just declare your opinion. – Mad Scientist Mar 24 '11 at 18:45
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I said Peer-Reviewed **Double Blind** Study. There is a huge difference. – Mar 24 '11 at 18:51
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Edited to make less inflammatory. Daniel - please use the comments only for talking about the question. We have a [chat](http://chat.stackexchange.com/) for extended discussion. – Sklivvz Mar 24 '11 at 18:58
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11Demanding that a double blind study be performed would be an unethical practice. You realize that it would intentionally expose subjects who were getting the non-effective vaccine to potentially deadly diseases. Of course, since when have ethical standards ever applied to anti-vaxers? – Larian LeQuella Mar 25 '11 at 01:44
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That are just a few results from a quick search, there are studies done for every approved vaccine. I'm using the US system as an example, but it will be similar in other countries. In the US the FDA has to approve vaccines:
Pre-marketing (pre-licensure) vaccine clinical trials are typically done in three phases, as is the case for any drug or biologic. Initial human studies, referred to as Phase 1, are safety and immunogenicity studies performed in a small number of closely monitored subjects. Phase 2 studies are dose-ranging studies and may enroll hundreds of subjects. Finally, Phase 3 trials typically enroll thousands of individuals and provide the critical documentation of effectiveness and important additional safety data required for licensing. At any stage of the clinical or animal studies, if data raise significant concerns about either safety or effectiveness, FDA may request additional information or studies, or may halt ongoing clinical studies.
So any vaccine will have to be shown safe and effective in clinical trials to get approved. They also continue to investigate the safety of the vaccines:
The FDA continues to oversee the production of vaccines after the vaccine and the manufacturing processes are approved, in order to ensure continuing safety.
Mad Scientist
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The answer to your question is "yes". Via PubMed:
- Efficacy, safety, and immunogenicity of a Vero-cell-culture-derived trivalent influenza vaccine: a multicentre, double-blind, randomised, placebo-controlled trial.
- Amplified antigen-specific immune responses in HIV-1 infected individuals in a double blind DNA immunization and therapy interruption trial.
- Trivalent inactivated influenza vaccine in African adults infected with human immunodeficient virus: double blind, randomized clinical trial of efficacy, immunogenicity, and safety.
- Safety, immunogenicity and duration of protection of the RTS,S/AS02(D) malaria vaccine: one year follow-up of a randomized controlled phase I/IIb trial.
ropable
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Russell Steen
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1@Daniel, it's a summary of the polio vaccine and does discuss the studies used to validate it. – Russell Steen Mar 24 '11 at 19:50
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It doesn't reference any of the claims it makes. It isn't peer-reviewed. It doesn't contain any data. Some points for being published by a museum, I guess, but the OP asks for actual gold-standard studies. – Oddthinking Jul 25 '11 at 18:01