D:\System Volume Information\DFSR
This is where DFSR (Distributed File System Replication) stores its database. DFSR maintains one Jet database per volume. If you put all your RFs on the same volume, they will all share the same database. So one possible solution is to separate some of your replicated folders onto different volumes.
Remove stuff from your DFSR RFs.
You can attempt to rebuild the database (thus bringing the file size down) by stopping the DFSR service, renaming the database, restarting the DFSR service, then deleting the old database after the new one has finished rebuilding and you've verified that it's healthy.
The intermediate folder (in DFS Configration) has 4096mo like quota.
Cool.
What are the differences between D:\Folder\Dfsrprivate
and D:\System Volume Information\DFSR?
Now you already know what the latter one is. The Dfsrprivate folder, as the name implies, contains data that is relevant to the internal workings of the DFSR service. For instance, each replicated folder has its own staging folder, which by default is located under the local path of the replicated folder in the DfsrPrivate\Staging directory. Each replicated folder also has its own Conflict and Deleted folder, which is located under the local path of the replicated folder in the DfsrPrivate\ConflictandDeleted. This is where files are put during deletions and conflict resolutions between replication partners. There are also some configuration files in there.