It really depends on what you're trying to accomplish.
In my case, the goal was to simply provide members of the public with a basic desktop experience via thin-clients. Since there was no demand for anything other than Microsoft Office and Web browsing, we decided to go with the Remote Desktop Services model where each thin-client simply remoted into a single, locked-down virtual machine running Server 2012R2.
The original purchaser of the equipment bought Wyse T50s, but in hindsight, I wish he'd purchased Windows Embedded thin clients for simpler centralized management within a completely Windows-based network.
I can see how a full VDI infrastructure would be appropriate for larger-scale operations that require complex application delivery, permission/access rules and the like, but given the simplicity of what we were trying to achieve, Remote Desktop Connections to the Virtual Machine did the job.