Overall, I love the SuperFetch feature in Vista and believe it results in hugely noticeable gains in the launch time and overall "snappiness" of the system. However, sometimes it apparently gets "bored" and attempts to cache huge files in the background that are much too large to fit in available RAM in the first place, such as virtual machine disk files and backup images.
I have searched high and low to no avail for a way to do file exclusions for this reason. Does anybody know if this is possible (or maybe on the wish list for Windows 7)?