We've come into the office (30+ networked systems) this morning to find that our email server is blacklisted on the CBL for:
This IP address is infected with, or is NATting for a machine infected with the ZeroAccess botnet, also known as Sirefef. More information can be found from Wikipedia. It is most often used for bitcoin mining or click fraud, but as it contains a downloader portion, it can do anything.
The other developer and I tend to believe what organizations such as Spamhaus say and believe we have a virus somewhere. Our network administrators are leaning more towards it being our web server (AWS) which sends out receipts to customers through our in-house email server. The mail server acts as a relay but only allows connections internally or from the IP of our webserver.
What kind of rate do lists such as the CBL have for false positives, is an infection alert something which could be picked up by something which is very much a very generic receipt?