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I am using pressflow 6 and NewRelic seems to suggest that memcache is infact hurting performance as shown below :

DB Vs Memcache Load

My settings.php file :

# Varnish reverse proxy on localhost
$conf['reverse_proxy'] = TRUE;           
$conf['reverse_proxy_addresses'] = array('127.0.0.1'); 

# Memcached configuration
$conf['cache_inc'] = './sites/all/modules/memcache/memcache.inc';
$conf['memcache_servers'] = array(
         '127.0.0.1:11211' => 'default',
         );
### END Mercury settings written on 2011-11-01T07:12:49-04:00
iTech
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