Sure.
Open notepad, and copy/paste the following into the file:
Windows Registry Editor Version 5.00
[HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Internet Settings]
"IEHardenIENoWarn"=dword:00000000
[HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Internet Settings\ZoneMap]
"IEHarden"=dword:00000000
Save the file as "IEHardenFix.reg" in a directory that all users have access to. In my case, I used my "Scripts" directory, but the %systemroot%\system32 works too.
Then, modify %systemroot%\system32\usrlogon.cmd. At the end, after the line that contains ":DONE" add a new line that looks like this:
regedit /s "%systemroot%\system32\IEHardenFix.reg"
Save and close the usrlogon.cmd file.
Now, when the users log on, this reg file will be silently imported into their registry, disabling the Enhanced Security Configuration for that user.
Hope this helps,
Glenn