I work for a small company (around 40 people) and our email is available via IMAP - but only when connected to our VPN. For iPhone users (and generally), the VPN connection appears to be an unnecessary overhead - after all, the IMAP traffic is encrypted and password-protected, so should I have any hesitations about opening up the IMAP SSL traffic to the internet?
(I can imagine greater concern for SMTP traffic perhaps - though, again, if encrypted and password protected, am I being overcautious?)