Yes, it is possible to deny traffic from source "any" for specific protocols / ports. Refer to the below screenshot.
Refer to the screenshot
Hierarchical firewall policies are created at organization and folder nodes. Creating a policy does not automatically apply the rules to the node. Policies once created can be applied to any nodes in the organization.
As said in the specifications of the Hierarchical firewall policies
Hierarchical firewall policies are containers for firewall rules. When you associate a policy with the organization or a folder, all rules are immediately applied. You can swap policies for a node, which automatically swaps all the firewall rules applied to virtual machine (VM) instances under that node. Each hierarchical firewall policy rule can include either IPv4 or IPv6 ranges, but not both.
Refer to the Create a Firewall Rule.