There are lots of ways to do this. I'm not sure there is a "best" way but here's my opinion:
It is light stuff - maybe 5# for a 4x7 piece of it. They sell them at the Home Depot in 42"x84" pieces and they're about 5# maybe.
I like panels I can easily handle by myself - 12' wide is as wide as I would go. A 50' roll would yield four ~12' sections (each cut you make will remove about 6" of length if they are 6"x10" holes) so you'll have, roughly lengths of 12'.
At 12' I'd drive a T-post or a U-post every 6' to create a sturdy trellis. Then just buy a roll of galvanized wire and wire them up to the posts. You could attach them any number of ways. I end up having a lot of twine from hay bales here that I save and that works well enough for the season. At the end of the season I cut the twine and toss it.
Of course you can cut them whatever length you want. My ground isn't necessarily flat so panels let me adjust to the terrain. With the roll I found it buckles just a bit - not a big deal but I also had to roll it up and hump it around the farm in a big roll... not ideal.