Zollinger–Ellison syndrome
Zollinger–Ellison syndrome (Z-E syndrome) is rare disease in which tumors cause the stomach to produce too much acid, resulting in peptic ulcers. Symptoms include abdominal pain and diarrhea.
| Zollinger–Ellison syndrome | |
|---|---|
| Other names | gastrinoma, pancreatic ulcerogenic tumor syndrome, ZES, Z-E syndrome |
| Endoscopy image of multiple small ulcers in the distal duodenum in a patient with Zollinger–Ellison syndrome | |
| Specialty | Endocrinology |
| Causes | Gastrinoma |
The syndrome is caused by a gastrinoma, a neuroendocrine tumor that secretes a hormone called gastrin. Too much gastrin in the blood (hypergastrinemia) results in the overproduction of gastric acid by parietal cells in the stomach. Gastrinomas most commonly arise in the duodenum, pancreas or stomach.
In 75% of cases Zollinger–Ellison syndrome occurs sporadically, while in 25% of cases it occurs as part of an autosomal dominant syndrome called multiple endocrine neoplasia type 1 (MEN 1).
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