Zoledronic acid

Zoledronic acid
Clinical data
Trade names	Reclast, Zometa, others
Other names	zoledronate
AHFS/Drugs.com	Monograph
MedlinePlus	a605023
License data	EU EMA: by INN; US DailyMed: Zoledronic_acid; US FDA: Zoledronic_acid;
Pregnancy; category	AU: B3;
Routes of; administration	Intravenous
Drug class	Bisphosphonate
ATC code	M05BA08 (WHO) ;
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Pharmacokinetic data
Protein binding	22%
Metabolism	Nil
Elimination half-life	146 hours
Excretion	Kidney (partial)
Identifiers
	IUPAC name [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid);
CAS Number	118072-93-8;
PubChem CID	68740;
IUPHAR/BPS	3177;
DrugBank	DB00399;
ChemSpider	61986;
UNII	70HZ18PH24;
KEGG	D08689 ; D01968 ;
ChEBI	CHEBI:46557;
ChEMBL	ChEMBL924 ;
PDB ligand	ZOL (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID0042668 ;
Chemical and physical data
Formula	C5H10N2O7P2
Molar mass	272.090 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=P(O)(O)C(O)(Cn1ccnc1)P(=O)(O)O;
	InChI InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14); Key:XRASPMIURGNCCH-UHFFFAOYSA-N;
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Zoledronic acid, also known as zoledronate and sold under the brand name Zometa by Novartis among others, is a medication used to treat a number of bone diseases. These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone and Duchenne muscular dystrophy (DMD). It is given by injection into a vein.

Common side effects include fever, joint pain, high blood pressure, diarrhea, and feeling tired. Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw. Use during pregnancy may result in harm to the baby. It is in the bisphosphonate family of medications. It works by blocking the activity of osteoclast cells and thus decreases the breakdown of bone.

Zoledronic acid was patented in 1986 and approved for medical use in the United States in 2001. It is on the World Health Organization's List of Essential Medicines.

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