Daclizumab
Daclizumab (trade name Zinbryta) is a therapeutic humanized monoclonal antibody which was used for the treatment of adults with relapsing forms of multiple sclerosis (MS). Daclizumab works by binding to CD25, the alpha subunit of the IL-2 receptor of T-cells.
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | CD25 |
| Clinical data | |
| Trade names | Zinbryta (multiple sclerosis) Zenapax (acute transplant rejection, discontinued in 2009) |
| AHFS/Drugs.com | zinbryta |
| License data | |
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| Routes of administration | Subcutaneous injection (MS) Intravenous (transplant rejection, discontinued) |
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| Pharmacokinetic data | |
| Bioavailability | 90% |
| Metabolism | Proteases |
| Elimination half-life | 21 days (11–38 days) |
| Identifiers | |
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| Chemical and physical data | |
| Formula | C6332H9808N1678O1989S42 |
| Molar mass | 142612.39 g·mol−1 |
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In March 2018, it was voluntarily withdrawn from the market by Biogen and Abbvie after reports of autoimmune encephalitis in Europe.
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