ZP3

ZP3
Identifiers
Aliases	ZP3, ZP3A, ZP3B, ZPC, Zp-3, zona pellucida glycoprotein 3 (sperm receptor), zona pellucida glycoprotein 3, OOMD3
External IDs	OMIM: 182889 MGI: 99215 HomoloGene: 5178 GeneCards: ZP3
Gene location (Human)
Chr.	Chromosome 7 (human)
End	76,442,071 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	136,017,478 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; muscle tissue; ; body of pancreas; ; nucleus accumbens; ; fundus; ; skeletal muscle tissue; ; gastric mucosa; ; putamen; ; right uterine tube; ; blood;
	Top expressed in
	secondary oocyte; ; egg cell; ; morula; ; ovary; ; blastocyst; ; cumulus cell; ; pancreas; ; spermatid; ; facial motor nucleus; ; foregut;
	More reference expression data
	n/a
Gene ontology
Molecular function	acrosin binding; protein binding; carbohydrate binding; identical protein binding; receptor ligand activity; extracellular matrix structural constituent; structural constituent of egg coat;
Cellular component	integral component of membrane; membrane; extracellular matrix; plasma membrane; extracellular region; extracellular space; intracellular anatomical structure; collagen-containing extracellular matrix;
Biological process	positive regulation of inflammatory response; positive regulation of leukocyte migration; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of antral ovarian follicle growth; positive regulation of interferon-gamma production; blastocyst formation; positive regulation of interleukin-4 production; oocyte development; positive regulation of type IV hypersensitivity; positive regulation of transcription, DNA-templated; humoral immune response mediated by circulating immunoglobulin; positive regulation of acrosome reaction; positive regulation of humoral immune response; positive regulation of T cell proliferation; binding of sperm to zona pellucida; negative regulation of binding of sperm to zona pellucida; positive regulation of ovarian follicle development; positive regulation of acrosomal vesicle exocytosis; negative regulation of transcription, DNA-templated; phosphatidylinositol-mediated signaling; single fertilization; egg coat formation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	7784
	22788
	ENSG00000188372
	ENSMUSG00000004948
	P21754
	P10761
	NM_007155; NM_001110354
	NM_011776
	NP_001103824; NP_009086
	NP_035906
	Wikidata
View/Edit Human	View/Edit Mouse

Zona pellucida sperm-binding protein 3, also known as zona pellucida glycoprotein 3 (Zp-3) or the sperm receptor, is a ZP module-containing protein that in humans is encoded by the ZP3 gene. ZP3 is the glycoprotein in the zona pellucida most important for inducting the acrosome reaction of sperm cells at the beginning of fertilization.

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