Tight junction protein 1

TJP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H2B, 2H2C, 2H3M, 2JWE, 2KXR, 2KXS, 2RCZ, 3CYY, 3LH5, 3SHU, 3SHW, 3TSV, 3TSW, 3TSZ, 4OEO, 4OEP, 4Q2Q, 4YYX
Identifiers
Aliases	TJP1, ZO-1, Tight junction protein 1
External IDs	OMIM: 601009 MGI: 98759 HomoloGene: 2445 GeneCards: TJP1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	29,968,915 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	65,177,529 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; sural nerve; ; placenta; ; right lung; ; smooth muscle tissue; ; Achilles tendon; ; endometrium; ; putamen; ; amygdala; ; myometrium;
	Top expressed in
	left lung lobe; ; utricle; ; stria vascularis; ; external carotid artery; ; cumulus cell; ; iris; ; conjunctival fornix; ; primitive streak; ; right lung; ; ciliary body;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calmodulin binding; protein binding; cadherin binding; protein domain specific binding; connexin binding; protein C-terminus binding;
Cellular component	membrane; bicellular tight junction; plasma membrane; basolateral plasma membrane; gap junction; apical junction complex; cytosol; cytoplasm; apical part of cell; cell junction; podosome; cell projection; nucleus; cell-cell junction; adherens junction; intercalated disc; apical plasma membrane; apicolateral plasma membrane; intercellular canaliculus; tight junctions; protein-containing complex;
Biological process	establishment of endothelial intestinal barrier; hippo signaling; cell-cell junction assembly; regulation of bicellular tight junction assembly; blastocyst formation; sensory perception of sound; response to lipopolysaccharide; negative regulation of vascular permeability; response to ethanol; response to magnetism; cellular response to glucose stimulus;
	Sources:Amigo / QuickGO
Orthologs
	7082
	21872
	ENSG00000277401; ENSG00000104067
	ENSMUSG00000030516
	Q07157
	P39447
NM_001301025; NM_001301026; NM_003257; NM_175610; NM_001330239;
	NM_001355012; NM_001355013; NM_001355014; NM_001355015
	NM_001163574; NM_009386
NP_001287954; NP_001287955; NP_001317168; NP_003248; NP_783297;
	NP_001341941; NP_001341942; NP_001341943; NP_001341944; NP_001287954.1; NP_001287955.1
	NP_001157046; NP_033412
	Wikidata
View/Edit Human	View/Edit Mouse

Zonula occludens-1 ZO-1, also known as Tight junction protein-1 is a 220-kD peripheral membrane protein that is encoded by the TJP1 gene in humans. It belongs to the family of zonula occludens proteins (ZO-1, ZO-2, and ZO-3), which are tight junction-associated proteins and of which, ZO-1 is the first to be cloned. It was first isolated in 1986 by Stevenson and Goodenough using a monoclonal antibody raised in rodent liver to recognise a 225-kD polypeptide in whole liver homogenates and in tight junction-enriched membrane fractions. It has a role as a scaffold protein which cross-links and anchors Tight Junction (TJ) strand proteins, which are fibril-like structures within the lipid bilayer, to the actin cytoskeleton.

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