ZK-93426

ZK-93426
Names
	Preferred IUPAC name Ethyl 4-methyl-5-[(propan-2-yl)oxy]-9H-pyrido[3,4-b]indole-3-carboxylate
	Other names ZK-93426; Ethyl 5-isopropoxy-4-methyl-9H-β-carboline-3-carboxylate
Identifiers
CAS Number	89592-45-0 ;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1271047 ;
ChemSpider	103086 ;
IUPHAR/BPS	4347;
PubChem CID	115210;
CompTox Dashboard (EPA)	DTXSID401008889 ;
	InChI InChI=1S/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3 Key: VMDUABMKBUKKPG-UHFFFAOYSA-N ; InChI=1/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3 Key: VMDUABMKBUKKPG-UHFFFAOYAG;
	SMILES CCOC(=O)C1=NC=C2C(=C1C)C3=C(N2)C=CC=C3OC(C)C;
Properties
Chemical formula	C18H20N2O3
Molar mass	314.336 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

ZK-93426 (ethyl-5-isopropoxy-4-methyl-beta-carboline-3-carboxylate) is a drug from the beta-carboline family. It acts as a weak partial inverse agonist of benzodiazepine receptors, meaning that it causes the opposite effects to the benzodiazepine class of drugs and has anxiogenic properties, although unlike most benzodiazepine antagonists it is not a convulsant and actually has weak anticonvulsant effects. In human tests it produced alertness, restlessness and feelings of apprehension, and reversed the effect of the benzodiazepine lormetazepam. It was also shown to produce nootropic effects and increased release of acetylcholine.

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