PDX1

PDX1
Identifiers
Aliases	PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PAGEN1, PDX-1, STF-1, pancreatic and duodenal homeobox 1
External IDs	OMIM: 600733 MGI: 102851 HomoloGene: 175 GeneCards: PDX1
Gene location (Human)
Chr.	Chromosome 13 (human)
End	27,926,313 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	147,212,658 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; body of pancreas; ; duodenum; ; gallbladder; ; liver; ; rectum; ; right lobe of liver; ; stomach; ; kidney; ; body of stomach;
	Top expressed in
	endocrine pancreas; ; islet of Langerhans; ; duodenum; ; pyloric antrum; ; humerus; ; Meckel's cartilage; ; mucous cell of stomach; ; secondary oocyte; ; occiput; ; occipital bone;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription factor binding; protein-containing complex binding; protein heterodimerization activity; promoter-specific chromatin binding;
Cellular component	cytoplasm; cytosol; nuclear speck; intracellular anatomical structure; nucleus; nucleoplasm;
Biological process	exocrine pancreas development; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; cell differentiation; regulation of transcription, DNA-templated; glucose homeostasis; regulation of transcription by RNA polymerase II; insulin secretion; negative regulation of transcription by RNA polymerase II; generation of precursor metabolites and energy; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; regulation of cell population proliferation; positive regulation of cell population proliferation; nitric oxide mediated signal transduction; glucose metabolic process; animal organ morphogenesis; pancreas development; liver development; positive regulation of insulin secretion involved in cellular response to glucose stimulus; morphogenesis of embryonic epithelium; digestive tract development; negative regulation of type B pancreatic cell apoptotic process; negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; endocrine pancreas development; type B pancreatic cell differentiation; transcription by RNA polymerase II; detection of glucose; smoothened signaling pathway; central nervous system development; response to wounding; response to glucose; response to iron(II) ion; response to chlorate; regulation of gene expression; positive regulation of cell death; response to organic cyclic compound; animal organ regeneration; response to nutrient levels; positive regulation of insulin secretion; response to vitamin; response to lipid; response to cytokine; response to nicotine; response to leucine; response to alkaloid; positive regulation of DNA binding; negative regulation of transcription, DNA-templated; stem cell differentiation; response to glucocorticoid; transdifferentiation; response to fatty acid;
	Sources:Amigo / QuickGO
Orthologs
	3651
	18609
	ENSG00000139515
	ENSMUSG00000029644
	P52945
	P52946
	NM_000209
	NM_008814
	NP_000200
	NP_032840
	Wikidata
View/Edit Human	View/Edit Mouse

PDX1 (pancreatic and duodenal homeobox 1), also known as insulin promoter factor 1, is a transcription factor in the ParaHox gene cluster. In vertebrates, Pdx1 is necessary for pancreatic development, including β-cell maturation, and duodenal differentiation. In humans this protein is encoded by the PDX1 gene, which was formerly known as IPF1. The gene was originally identified in the clawed frog Xenopus laevis and is present widely across the evolutionary diversity of bilaterian animals, although it has been lost in evolution in arthropods and nematodes. Despite the gene name being Pdx1, there is no Pdx2 gene in most animals; single-copy Pdx1 orthologs have been identified in all mammals. Coelacanth and cartilaginous fish are, so far, the only vertebrates shown to have two Pdx genes, Pdx1 and Pdx2.

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